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- $Unique_ID{BRK03340}
- $Pretitle{}
- $Title{sulindac}
- $Subject{Clinoril Merck Sharp Dohme Nonsteroidal anti-inflammatory analgesic
- sulindac inflammation pain swelling stiffness arthritis gout bursitis
- tendinitis prostaglandins}
- $Volume{}
- $Log{
- Clinoril*0334001.scf}
-
- Copyright (C) 1993 Publications International, Ltd.
-
-
- sulindac
- ------------------------------------------------------------------------------
-
- BRAND NAME (Manufacturer)
-
- Clinoril (Merck Sharp & Dohme)
-
- TYPE OF DRUG
-
- Nonsteroidal anti-inflammatory analgesic
-
- INGREDIENT
-
- sulindac
-
- DOSAGE FORM
-
- Tablets (150 mg and 200 mg)
-
- STORAGE
-
- This medication should be stored in a closed container at room
- temperature away from heat and direct sunlight.
-
- USES
-
- Sulindac is used to treat the inflammation (pain, swelling, and
- stiffness) of certain types of arthritis, gout, bursitis, and tendinitis.
- Sulindac has been shown to block the production of certain body chemicals,
- called prostaglandins, that may trigger pain. However, it is not fully
- understood how sulindac works.
-
- TREATMENT
-
- To decrease stomach irritation, your doctor may want you to take this
- medication with food or antacids.
- It is important to take sulindac on schedule and not to miss any doses.
- If you do miss a dose, take it as soon as possible, unless it is almost time
- for your next dose. In that case, do not take the missed dose at all; just
- return to your regular dosing schedule. Do not double the next dose.
- If you are taking sulindac to relieve arthritis, you must take it
- regularly, as directed by your doctor. It may take up to three weeks for you
- to feel the full benefits of this medication. Sulindac does not cure
- arthritis, but it will help to control the condition as long as you continue
- to take it.
-
- SIDE EFFECTS
-
- Minor.
-
- Bloating, constipation, diarrhea, difficulty in sleeping, dizziness,
- drowsiness, headache, heartburn, indigestion, light-headedness, loss of
- appetite, nausea, nervousness, soreness of the mouth, unusual sweating, or
- vomiting. As you adjust to the medication, these side effects should stop.
- To relieve constipation, increase the amount of fiber in your diet (fresh
- fruits and vegetables, salads, bran, and whole-grain breads), exercise, and
- drink more water (unless your doctor directs you to do otherwise).
- If you become dizzy or light-headed while taking this drug, sit or lie
- down for a while; get up slowly from a sitting or reclining position; and be
- careful on stairs. Also, be especially careful when driving an automobile or
- operating potentially dangerous equipment.
-
- Major.
-
- Tell your doctor about any side effects that are persistent or
- particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
- bloody or black, tarry stools; blurred vision; chills; confusion; depression;
- difficulty in breathing; difficulty in hearing; difficult or painful
- urination; palpitations; ringing or buzzing in the ears; skin rash, hives, or
- itching; stomach pain; swelling; tightness in the chest; unexplained sore
- throat and fever; unusual bleeding or bruising; unusual fatigue or weakness;
- unusual weight gain; vaginal bleeding; wheezing; or yellowing of the eyes or
- skin.
-
- INTERACTIONS
-
- Sulindac interacts with several types of medications:
- 1. The combination of anticoagulants (blood thinners, such as warfarin)
- and sulindac can lead to an increase in bleeding complications.
- 2. Aspirin, salicylates, or other anti-inflammatory medications can cause
- an increase in stomach irritation.
- 3. Probenecid can increase the amount of sulindac in the bloodstream when
- the drugs are taken concurrently.
- 4. The blood-pressure-lowering effects of beta blockers may be decreased
- by this drug.
- 5. This medication may interact with diuretics (water pills) and cause an
- increase in the effects of the diuretic.
- BE SURE TO TELL YOUR DOCTOR about any medications you are currently
- taking, especially any of those listed above.
-
- WARNINGS
-
- * Be sure to tell your doctor if you have ever had unusual or allergic
- reactions to sulindac or any of the other chemically related medications
- (including aspirin and other salicylates, diclofenac, diflunisal, etodoloc,
- fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, meclofenamate,
- mefenamic acid, nabumetone, naproxen, oxyphenbutazone, phenylbutazone,
- piroxicam, and tolmetin).
- * Be sure to tell your doctor if you have ever had asthma, bleeding
- problems, colitis, stomach ulcers or other stomach problems, epilepsy, heart
- disease, high blood pressure, kidney disease, liver disease, mental illness,
- or Parkinson's disease.
- * If sulindac makes you dizzy or drowsy, do not take part in any activity
- that requires alertness, such as driving a car or operating potentially
- dangerous machinery.
- * Be sure to tell your doctor or dentist that you are taking this
- medication before having surgery or any other type of medical or dental
- treatment.
- * Stomach problems are more likely to occur if you take aspirin or other
- salicylates regularly or drink alcoholic beverages while being treated with
- this medication. These should be avoided (unless your doctor directs you to
- do otherwise).
- * Be sure to tell your doctor if you are pregnant. The safe use of this
- medication in human pregnancy has not been established. Side effects have
- been observed in the development of bones and organs in the offspring of
- animals that received sulindac during pregnancy. If taken late in pregnancy,
- this type of drug can also prolong labor. Also, tell your doctor if you are
- currently breast-feeding an infant. Small amounts of sulindac have been shown
- to pass into breast milk.
-
- ----------------
-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
-